The MES-2/MES-3/MES-6 Complex and Regulation of Histone H3 Methylation in C. elegans
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The MES-2/MES-3/MES-6 Complex and Regulation of Histone H3 Methylation in C. elegans
The C. elegans proteins MES-2 and MES-6, orthologs of the Polycomb group (PcG) chromatin repressors E(Z) and ESC, exist in a complex with their novel partner MES-3. The MES system participates in silencing the X chromosomes in the hermaphrodite germline. Loss of maternal MES function leads to germline degeneration and sterility. We report here that the MES complex is responsible for di- and tri...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2004
ISSN: 0960-9822
DOI: 10.1016/j.cub.2004.08.062